Best Online MSN Programs in South Carolina

Many nurses in South Carolina aspire to advance their careers by taking on more independent and fulfilling roles. However, the educational requirements can sometimes feel like a hurdle. For example, becoming a nurse practitioner requires earning a Master of Nursing Science (MSN) to qualify for licensure. The good news is that MSN programs in South Carolina are often affordable and can be completed relatively quickly, even in the state’s more affluent areas. From the bustling cities of Charleston and Columbia to quieter suburban communities, a variety of MSN programs are available to meet diverse needs. Below are some recommendations for finding the fastest and most cost-effective MSN programs in the Palmetto State, along with tips to streamline your application process.

2025 - Best Online MSN Programs in South Carolina

RegisteredNursing.org has ranked the Best Online Master of Science in Nursing (MSN) Programs in South Carolina for 2025. These programs are noted for their academic excellence, flexible learning formats, and commitment to advancing the nursing profession. Rankings are determined using a detailed methodology evaluating program quality, accessibility, and student outcomes. Learn more on our rankings methodology page.

1.

Anderson University

Greenville, SC

Anderson University's MSN programs are renowned for their commitment to excellence and innovation in nursing education. The nursing department, known as the School of Nursing and Health Professions, is dedicated to providing students with a holistic and patient-centered approach to healthcare. With a strong emphasis on evidence-based practice and interdisciplinary collaboration, Anderson University prepares future nurses to be leaders in the ever-evolving field of healthcare.

MSN Programs

• Family Nurse Practitioner Online/Hybrid
• Nurse Educator Online/Hybrid
• Psychiatric Mental Health Nurse Practitioner Online/Hybrid

2.

Charleston Southern University

Charleston, SC

Charleston Southern University offers MSN programs through the College of Nursing, providing students with a comprehensive and rigorous curriculum to prepare them for advanced nursing roles. The nursing department emphasizes evidence-based practice, patient-centered care, and leadership development. With small class sizes and experienced faculty, CSU's MSN programs offer a personalized and supportive learning environment for aspiring nurse leaders.

MSN Programs

• Nursing Education Online/Hybrid
• Nursing Leadership and Healthcare Administration Online/Hybrid

3.

Francis Marion University

Florence, SC

Francis Marion University offers rigorous and comprehensive MSN programs through its esteemed nursing department. The university's commitment to academic excellence and hands-on learning opportunities prepares students to become leaders in the ever-evolving field of nursing. With a focus on evidence-based practices and patient-centered care, FMU's nursing philosophies instill a strong sense of professionalism and compassion in its graduates.

MSN Programs

• Family Nurse Practitioner Online/Hybrid
• Nurse Educator Online/Hybrid
• Psychiatric Mental Health Nurse Practitioner Online/Hybrid

RN to MSN Programs in South Carolina

Typical admissions requirements for RN to MSN programs include:

• South Carolina RN license
• ADN or nursing diploma
• GPA transcripts (usually 3.0 or higher)
• Professional nursing experience (often 1–2 years of clinical practice)
• Letters of recommendation, a personal statement, and/or a resume

If you’re looking for a good example of RN to MSN programs in South Carolina, take a look at either the University of South Carolina (USC) or Clemson University, both of which offer this convenient bridge program.

Fast & Affordable MSN Programs in South Carolina

While South Carolina offers a variety of MSN programs, finding fast and affordable options can significantly benefit students looking to advance their careers. Below, we'll highlight some of the quickest MSN programs in South Carolina, as well as those that provide the best value for your investment.

What Are the Fastest Online MSN Programs?

The time required to complete an MSN program in South Carolina largely depends on your enrollment status and the program type. Full-time students can often finish their MSN in as little as two years, while part-time students may take up to six years. This flexibility makes MSN programs one of the most efficient and accessible pathways for nurses pursuing advanced education. With accelerated and online options available, many students can shorten this timeline further, making it an excellent choice for those ready to advance their careers quickly. Below are a few examples of programs available in the state:

What Are the Most Affordable Online MSN Programs?

MSN degree programs are often regarded as one of the most cost-effective pathways for nurses pursuing graduate-level education, thanks to their relatively short duration. In South Carolina, the affordability of an MSN program depends on several factors, including the school you select, program size, and additional expenses like living costs, textbooks, and technology fees. Establishing residency in South Carolina before enrolling can also help reduce tuition costs by qualifying for in-state rates. By thoroughly researching and comparing programs, prospective students can find options that fit both their budget and career aspirations. If you’re searching for an affordable MSN program in South Carolina, consider options from the schools listed below:

Accelerated MSN & Master's Entry to Nursing Practice (MENP) 

If you hold a bachelor's degree in a non-nursing field, an Accelerated MSN & Master's Entry to Nursing Practice (MENP) program in South Carolina offers an excellent pathway to transition into nursing. These programs enable you to pursue an MSN without first obtaining a BSN, saving both time and money compared to traditional routes. MENP programs are structured to efficiently prepare students with the skills and knowledge required for advanced nursing roles. Below are the typical admissions requirements for MENP programs to guide you through the application process.

• Bachelor's degree
• Minimum GPA (often 3.0+)
• GRE or TEAS scores (if required)
• Transcripts, recommendations, personal statement, resume
• Healthcare experience (preferred or required)
• Admissions interview

If you think you may be eligible to apply, take a look at University of South Carolina (USC) and Clemson University.

Schools Offering Popular MSN Specialties

One of the most appealing aspects of pursuing a graduate nursing degree in South Carolina is the wide range of specialties available to focus your studies. Specializing not only enhances your expertise but also boosts job security and increases your earning potential. Below are a few examples of MSN programs in South Carolina that offer specialized tracks in various areas:

What is MSN Accreditation?

MSN accreditation in South Carolina ensures that programs adhere to high-quality standards set by respected accrediting organizations like the Commission on Collegiate Nursing Education (CCNE) and the Accreditation Commission for Education in Nursing (ACEN). Accreditation validates that the curriculum, faculty, and program outcomes effectively prepare students for advanced nursing roles, licensure, and certification. Graduating from an accredited MSN program is essential, as students from non-accredited programs cannot qualify for licensure or certification—critical steps for career advancement in nursing.

2025 List of MSN Programs in South Carolina

Check out the full list of MSNs located in South Carolina below:

MSN Programs By City:

• Columbia MSN Programs
• Charleston MSN Programs