Best Online MSN Programs in South Carolina
- 2025 - Best Online MSN Programs in South Carolina
- RN to MSN Programs in South Carolina
- Fast & Affordable MSN Programs in South Carolina
- Accelerated MSN & Master's Entry to Nursing Practice (MENP)
- Schools Offering Popular MSN Specialties
- What is MSN Accreditation?
- 2025 List of MSN Programs in South Carolina

Many nurses in South Carolina aspire to advance their careers by taking on more independent and fulfilling roles. However, the educational requirements can sometimes feel like a hurdle. For example, becoming a nurse practitioner requires earning a Master of Nursing Science (MSN) to qualify for licensure. The good news is that MSN programs in South Carolina are often affordable and can be completed relatively quickly, even in the state’s more affluent areas. From the bustling cities of Charleston and Columbia to quieter suburban communities, a variety of MSN programs are available to meet diverse needs. Below are some recommendations for finding the fastest and most cost-effective MSN programs in the Palmetto State, along with tips to streamline your application process.
2025 - Best Online MSN Programs in South Carolina

RegisteredNursing.org has ranked the Best Online Master of Science in Nursing (MSN) Programs in South Carolina for 2025. These programs are noted for their academic excellence, flexible learning formats, and commitment to advancing the nursing profession. Rankings are determined using a detailed methodology evaluating program quality, accessibility, and student outcomes. Learn more on our rankings methodology page.
Anderson University
Anderson University's MSN programs are renowned for their commitment to excellence and innovation in nursing education. The nursing department, known as the School of Nursing and Health Professions, is dedicated to providing students with a holistic and patient-centered approach to healthcare. With a strong emphasis on evidence-based practice and interdisciplinary collaboration, Anderson University prepares future nurses to be leaders in the ever-evolving field of healthcare.
MSN Programs- Family Nurse Practitioner Online/Hybrid
- Nurse Educator Online/Hybrid
- Psychiatric Mental Health Nurse Practitioner Online/Hybrid

Charleston Southern University
Charleston Southern University offers MSN programs through the College of Nursing, providing students with a comprehensive and rigorous curriculum to prepare them for advanced nursing roles. The nursing department emphasizes evidence-based practice, patient-centered care, and leadership development. With small class sizes and experienced faculty, CSU's MSN programs offer a personalized and supportive learning environment for aspiring nurse leaders.
MSN Programs- Nursing Education Online/Hybrid
- Nursing Leadership and Healthcare Administration Online/Hybrid

Francis Marion University
Francis Marion University offers rigorous and comprehensive MSN programs through its esteemed nursing department. The university's commitment to academic excellence and hands-on learning opportunities prepares students to become leaders in the ever-evolving field of nursing. With a focus on evidence-based practices and patient-centered care, FMU's nursing philosophies instill a strong sense of professionalism and compassion in its graduates.
MSN Programs- Family Nurse Practitioner Online/Hybrid
- Nurse Educator Online/Hybrid
- Psychiatric Mental Health Nurse Practitioner Online/Hybrid

RN to MSN Programs in South Carolina
Typical admissions requirements for RN to MSN programs include:
- South Carolina RN license
- ADN or nursing diploma
- GPA transcripts (usually 3.0 or higher)
- Professional nursing experience (often 1–2 years of clinical practice)
- Letters of recommendation, a personal statement, and/or a resume
If you’re looking for a good example of RN to MSN programs in South Carolina, take a look at either the University of South Carolina (USC) or Clemson University, both of which offer this convenient bridge program.
Fast & Affordable MSN Programs in South Carolina
While South Carolina offers a variety of MSN programs, finding fast and affordable options can significantly benefit students looking to advance their careers. Below, we'll highlight some of the quickest MSN programs in South Carolina, as well as those that provide the best value for your investment.
What Are the Fastest Online MSN Programs?
The time required to complete an MSN program in South Carolina largely depends on your enrollment status and the program type. Full-time students can often finish their MSN in as little as two years, while part-time students may take up to six years. This flexibility makes MSN programs one of the most efficient and accessible pathways for nurses pursuing advanced education. With accelerated and online options available, many students can shorten this timeline further, making it an excellent choice for those ready to advance their careers quickly. Below are a few examples of programs available in the state:
School | Estimated Length | Online Option? |
Medical University of South Carolina (MUSC) | 12 – 18 Months | Yes |
Charleston Southern University (CSU) | 19 Months | Yes |
University of South Carolina (USC) | 5 Semesters | Yes |
What Are the Most Affordable Online MSN Programs?
MSN degree programs are often regarded as one of the most cost-effective pathways for nurses pursuing graduate-level education, thanks to their relatively short duration. In South Carolina, the affordability of an MSN program depends on several factors, including the school you select, program size, and additional expenses like living costs, textbooks, and technology fees. Establishing residency in South Carolina before enrolling can also help reduce tuition costs by qualifying for in-state rates. By thoroughly researching and comparing programs, prospective students can find options that fit both their budget and career aspirations. If you’re searching for an affordable MSN program in South Carolina, consider options from the schools listed below:
School | Estimated Cost | Credits |
Francis Marion University (FMU) | $25,000 – $35,000 | 55 |
Lander University (LU) | $14,000 – $20,000 | 36 |
University of South Carolina (USC) | $25,000 – $30,000 | 39 |
Accelerated MSN & Master's Entry to Nursing Practice (MENP)
If you hold a bachelor's degree in a non-nursing field, an Accelerated MSN & Master's Entry to Nursing Practice (MENP) program in South Carolina offers an excellent pathway to transition into nursing. These programs enable you to pursue an MSN without first obtaining a BSN, saving both time and money compared to traditional routes. MENP programs are structured to efficiently prepare students with the skills and knowledge required for advanced nursing roles. Below are the typical admissions requirements for MENP programs to guide you through the application process.
- Bachelor's degree
- Minimum GPA (often 3.0+)
- GRE or TEAS scores (if required)
- Transcripts, recommendations, personal statement, resume
- Healthcare experience (preferred or required)
- Admissions interview
If you think you may be eligible to apply, take a look at University of South Carolina (USC) and Clemson University.
Schools Offering Popular MSN Specialties
One of the most appealing aspects of pursuing a graduate nursing degree in South Carolina is the wide range of specialties available to focus your studies. Specializing not only enhances your expertise but also boosts job security and increases your earning potential. Below are a few examples of MSN programs in South Carolina that offer specialized tracks in various areas:
School | Specialty | Credits |
Francis Marion University (FMU) | Family Nurse Practitioner | 55 |
University of South Carolina (USC) | Nursing Education | 39 |
Lander University (LU) | Clinical Nurse Leader | 36 |
What is MSN Accreditation?
MSN accreditation in South Carolina ensures that programs adhere to high-quality standards set by respected accrediting organizations like the Commission on Collegiate Nursing Education (CCNE) and the Accreditation Commission for Education in Nursing (ACEN). Accreditation validates that the curriculum, faculty, and program outcomes effectively prepare students for advanced nursing roles, licensure, and certification. Graduating from an accredited MSN program is essential, as students from non-accredited programs cannot qualify for licensure or certification—critical steps for career advancement in nursing.
2025 List of MSN Programs in South Carolina
Check out the full list of MSNs located in South Carolina below:
MSN Programs By City:
Anderson, SC
Anderson University
- Master's - MSN in Nursing: Nurse Educator
Online & Campus Based - Website
- Online flexible learning format
- Christian worldview integration
- Multiple nursing concentrations
- RN with ADN or BSN entry paths
- Practicing nurses as instructors
- Minimum 3.0 GPA required
- Active unencumbered RN license
- CPR certification needed
- Master's - Nursing: Executive Leadership, MSN
Online Learning - Website
- Online program
- 41 credit hours
- 400 clinical hours
- Executive Leadership focus
- Includes MBA-level courses
- National certification prep
- 3.2 GPA required
- Active RN license required
- Master's - MSN, Nursing: Psychiatric Mental Health Nurse Practitioner
Online & Campus Based - Website
- 51 total credit hours
- Hybrid program format
- 750 clinical training hours
- Covers all population age groups
- Bachelor's in Nursing required
- 1-2 years nursing experience recommended
- 5 semesters full-time option
- 8 semesters part-time option
- Master's - Nursing: Executive Leadership, MSN
Online & Campus Based - Website
- Online flexible program
- 41 credit hour curriculum
- 400 clinical hours
- Combines nursing, business courses
- Prepares for NEA-BC certification
- Mid-semester campus sessions
- 3.2 GPA admission requirement
- RN license prerequisite
Clemson, SC
Clemson University
- Master's - Master of Science, major in Nursing
Concentration: Nursing Educator - Campus Based - Website
- Offered in Greenville, SC
- Nurse Educator concentration
- Summer start (May)
- Minimum 3.25 GPA required
- 600+ clinical hours needed
- Three recommendation letters
- Application deadline Feb 15
- Clinical practice focus
- Master's - Adult-Gerontology Primary Care Nurse Practitioner
Online & Campus Based - Website
- Hybrid program delivery format
- Specialized adult/gerontology focus
- Practicum in primary care settings
- Minimum 3.25 GPA requirement
- Located in Greenville, SC campus
- Master's - Master of Science degree program with a major in Nursing
Concentration: Nurse Administration - Campus Based - Website
- Graduate courses at Greenville
- 600 hours nursing practice required
- Undergraduate accounting recommended
- Advanced nursing knowledge focus
- Leadership skill development
Columbia, SC
University of South Carolina-Columbia
- Master's - MSN in Nursing Informatics
Online Learning - Website
- 36 credit hours total
- Online distance format
- Full or part-time options
- No GRE required
- National certification preparation
- Flexible workplace practicum
- Minimum 3.0 GPA required
- 225 total clinical hours
- Master's - Nursing Education
Online Learning - Website
- Ranked #3 Online Graduate Nursing Program
- 39 credit hours, 5 semesters
- Fully online course delivery
- 500 total clinical hours
- No GRE required for admission
- 3.0 minimum GPA
- Fall and spring entry options
- National certification preparation
- Master's - Psychiatric Mental Health Nurse Practitioner
Online Learning - Website
- B.S.N. entry pathway
- 48-51 total credit hours
- National certification preparation
- Diverse practice settings
- Advanced clinical practicums
- 3.0 GPA requirement
- Evidence-based curriculum
- Psychopharmacology focus
- Master's - Adult Gerontology-Acute Care Nurse Practitioner
Online Learning - Website
- Online MSN program
- Acute care nurse practitioner focus
- Minimum 3.0 undergraduate GPA
- 1+ year nursing experience required
- National certification exam eligible
- Master's - Family Nurse Practitioner
Online Learning - Website
- Online program format
- Minimum 3.0 undergraduate GPA
- One year nursing experience required
- Summer and Fall entry
- BLS certification needed
- Professional recommendation required
- Primary care across lifespan focus
- State-specific authorization
Florence, SC
Francis Marion University
- Master's - MSN Family Nurse Practitioner
Online & Campus Based - Website
- 55 credit hour program
- 780 clinical practicum hours
- Fully online courses
- Fall semester admission
- Certification exam preparation
- 2.5 year full-time completion
- Part-time study option
- Lifespan primary care focus
- Master's - Psychiatric Mental Health Nurse Practitioner
Online & Campus Based - Website
- Hybrid program format.
- 55 semester hours required.
- 780 practicum hours.
- Eligible for national certification.
- Minimal campus visits.
- Focus on psychiatric mental health.
- Flexible for working professionals.
- Comprehensive knowledge and skills.
Gaffney, SC
Limestone University
- Master's - Master of Science in Nursing + Master of Business Administration Dual Degree
Concentration: Nursing Administration and Healthcare Administration - Online Learning - Website
- 100% Online Degree Program
- 36 Total Credit Hours
- Healthcare Industry Focus
- Tuition $1,950 per Course
- Prepares for Leadership Roles
- Flexible Learning Format
- Strategic Management Emphasis
- Master's - Master of Science in Nursing
Concentration: Administration - Online Learning - Website
- Online 10-course MSN program
- Completion in 18 months
- Leadership-focused curriculum
- Advanced healthcare administration
- Prepares for executive nursing roles
Greenwood, SC
Lander University
- Master's - Master of Science in Nursing: Clinical Nurse Leader
Online Learning - Website
- Online flexible graduate nursing program
- 500 clinical practice hours
- Two concentration options
- CCNE accredited program
- Advanced clinical leadership focus
- Minimum 3.0 undergraduate GPA
- Current RN licensure required
- Comprehensive clinical assessment courses
Hartsville, SC
Lander University
- Master's - Master of Science in Nursing: Clinical Nurse Leader
Online Learning - Website
- Online flexible graduate nursing program
- 500 clinical practice hours
- Two concentration options
- CCNE accredited program
- Advanced clinical leadership focus
- Minimum 3.0 undergraduate GPA
- Current RN licensure required
- Comprehensive clinical assessment courses