The State of North Carolina is known for its beautiful landscapes and thriving cities, but what many residents may not realize is that the state is home to a growing number of nurses, with demand continuing to rise in the coming years. Opportunities for both entry-level and higher-level nursing positions, such as nurse practitioner or nurse executives, are expanding rapidly. These advanced roles offer higher pay and more independence compared to traditional RN positions, but they require specialized education and training. If you're looking for an affordable and efficient way to gain this training, Master of Nursing Science (MSN) programs are often the best option. Learn how to find the quickest and most affordable MSN programs, whether in cities like Raleigh, Charlotte, or beyond, by exploring the sections below.

2025 - Best Online MSN Programs in North Carolina

RegisteredNursing.org has identified the Best Online Master of Science in Nursing (MSN) Programs in North Carolina for 2025. These programs are recognized for their academic excellence, flexible learning options, and commitment to advancing the nursing profession. Rankings are based on a comprehensive methodology evaluating program quality, accessibility, and student success. For more information, visit our rankings methodology page.

1.

Duke University

Durham, NC

Duke University's MSN programs, offered through the School of Nursing, provide students with a comprehensive education grounded in the school's philosophy of evidence-based practice, interdisciplinary collaboration, and leadership development. With a strong focus on clinical experience, Duke's MSN programs prepare nurses to excel in a rapidly changing healthcare landscape and make a positive impact on patient care.

MSN Programs
2.

Winston-Salem State University

Winston-Salem, NC

Winston-Salem State University's MSN programs are highly regarded for their commitment to diversity, innovation, and excellence in nursing education. With a strong focus on evidence-based practice and community engagement, the nursing department prides itself on producing leaders who are equipped to address the complex healthcare needs of today's society.

MSN Programs
3.

East Carolina University

Greenville, NC

East Carolina University offers a highly renowned MSN program through its esteemed College of Nursing, which follows a holistic approach to healthcare and emphasizes cultural competence and evidence-based practice. With state-of-the-art facilities and experienced faculty, ECU prepares nurses to be leaders in the constantly evolving healthcare landscape.

MSN Programs

RN to MSN Programs in North Carolina

An RN to MSN program is a specialized educational pathway designed for registered nurses who hold an associate degree in nursing (ADN) or a nursing diploma. These programs allow nurses to earn an MSN more efficiently by building on their existing nursing education and experience resulting in a faster and more affordable MSN education. RN to MSN programs often include both undergraduate and graduate coursework, enabling nurses to seamlessly transition into advanced practice roles, such as nurse practitioners, nurse educators, or healthcare administrators.

Typical admissions requirements for RN to MSN programs include:

  • North Carolina RN license
  • ADN or nursing diploma
  • GPA transcripts (usually 3.0 or higher)
  • Professional nursing experience (often 1–2 years of clinical practice)
  • Letters of recommendation, a personal statement, and/or a resume

If you’re ready to start applying, you can find RN to MSN programs offered by the University of North Carolina, Pembroke (UNCP) and the University of North Carolina, Charlotte. Check out all RN to MSN options in the state below:

Boiling Springs, NC

Hunt School of Nursing
110 S. Main St., P.O. Box 997
Boiling Springs, NC 28017

Chapel Hill, NC

School of Nursing
Carrington Hall, S Columbia St
Chapel Hill, NC 27599

Charlotte, NC

School of Nursing
9201 University City Blvd
Charlotte, NC 28223-0001

Cullowhee, NC

School of Nursing
1 University Way
Cullowhee, NC 28723

Pembroke, NC

Department of Nursing
1 University Drive
Pembroke, NC 28372-1510

Are we missing your school's program or need to update information listed? Please contact us so we can make the necessary changes.

Fast & Affordable MSN Programs in North Carolina

For full-time licensed nurses in North Carolina contemplating a career change, the cost of tuition and the time commitment required for graduate school are common concerns. Fortunately, North Carolina's MSN programs offer a significant advantage by addressing these challenges, making advanced nursing education more accessible and manageable.

What Are the Fastest Online MSN Programs?

If you're pursuing a traditional MSN program in North Carolina, you can generally expect a commitment of 3 to 4 years. However, not all MSN programs in North Carolina require this much time. By exploring your options, you might find online MSN programs or those offering summer courses that allow for a faster timeline. Some programs are inherently shorter than others. Below are a few examples to consider.

SchoolEstimated LengthOnline Option?
Belmont Abbey College (BAC)12 – 18 MonthsYes
University of North Carolina Wilmington (UNCW)12 MonthsYes
Winston-Salem State University (WSSU)2 YearsNo

What Are the Most Affordable Online MSN Programs?

If you're looking to save on MSN education, North Carolina provides several cost-effective options to explore. When evaluating programs, consider factors such as tuition rates, program size, additional fees, cost of living, and whether you qualify for in-state tuition. Below are a few schools in North Carolina known for offering affordable MSN programs.

SchoolEstimated CostCredits
Western North Carolina (WNC)$11,000 – $22,00038 – 39
Fayetteville State University (FSU)$13,000 – $63,00036
University of North Carolina, Pembroke (UNCP)$8,000 – $12,00039

Accelerated MSN & Master's Entry to Nursing Practice (MENP)

Accelerated MSN & Master's Entry to Nursing Practice (MENP) programs are designed for individuals who have a bachelor's degree in a non-nursing field and want to transition into a nursing career. These programs combine the core components of both a BSN and an MSN into a comprehensive, fast-paced curriculum. By integrating foundational nursing education with advanced training, MENP programs offer a quicker and more economical route compared to earning each degree separately. Graduates are equipped for RN licensure as well as leadership or specialized positions in healthcare. Below are the common admissions requirements for MENP programs in North Carolina:

  • Bachelor's degree
  • Minimum GPA (often 3.0+)
  • GRE or TEAS scores (if required)
  • Transcripts, recommendations, personal statement, resume
  • Healthcare experience (preferred or required)
  • Admissions interview

To find MENP programs located in North Carolina, take a look at programs like University of North Carolina (UNC) and East Carolina University (ECU).

Schools Offering Popular MSN Specialties

When researching MSN programs in North Carolina, it’s essential to consider whether they provide options for specialization. Many programs allow students to focus their studies on areas such as family practice, psychiatric-mental health, or pediatrics. Choosing a specialization can elevate your career opportunities and tailor your education to match your professional aspirations. Below are examples of specialized MSN programs available in North Carolina.

SchoolSpecialtyCredits
University of North Carolina (UNC)Psych-Mental Health Nurse Practitioner58
Duke University (DU)Pediatric Primary Care Nurse Practitioner43
East Carolina University (ECU)Neonatal Nurse Practitioner42

What is MSN Accreditation?

One of the most critical factors to consider when selecting an MSN program in North Carolina is accreditation. MSN accreditation signifies that a program’s curriculum meets established quality standards set by the state board and national accrediting organizations. In the U.S., MSN programs are typically accredited by the Commission on Collegiate Nursing Education (CCNE) and the Accreditation Commission for Education in Nursing (ACEN). Completing an accredited program ensures eligibility for advanced nursing licensure and certification. Conversely, attending a non-accredited program may lead to complications in pursuing these credentials. Always confirm a program’s accreditation status before applying.

2025 List of MSN Programs in North Carolina

Still not sure which MSN program to go with? Keep researching the full list of MSN programs in the state:

MSN Programs By City:

Jump to City:

Boiling Springs, NC

Gardner-Webb University

  • Master's - Nursing/Business (MSN/MBA)

    Online Learning - Website

    • 54-credit hour program.
    • Combines nursing and business.
    • 24 nursing credit hours.
    • 30 business credit hours.
    • Start in August or January.
    • Online program format.
    • Focus on healthcare leadership.
    • Enhances decision-making skills.
  • Master's - Master of Science in Nursing

    Concentration: Nursing Education - Online Learning - Website

    • Fully online MSN program
    • Complete in 1 year
    • 8-week course terms
    • 30 total credit hours
    • Multiple start dates annually
    • Practicum in local settings
    • Seamless admission for GWU BSN grads
    • Christ-inspired patient care focus

Chapel Hill, NC

University of North Carolina at Chapel Hill

  • Master's - Adult-Gerontology Primary Care Nurse Practitioner

    Concentration: Oncology - Online Learning - Website

    • Master's level advanced nursing program
    • Specialized oncology concentration
    • Adult-Gerontology primary care focus
    • Advanced clinical skills training
    • Comprehensive patient care preparation
  • Master's - Psychiatric-Mental Health Nurse Practitioner

    Online Learning - Website

    • Advanced nursing practice specialization
    • Mental health clinical expertise
    • Graduate-level comprehensive training
    • Patient-centered care focus
    • Evidence-based treatment strategies
  • Master's - Adult-Gerontology Primary Care Nurse Practitioner

    Online Learning - Website

    • Online Master's in Nursing
    • Advanced Practice Specialization
    • Adult-Gerontology Focus
    • Comprehensive Clinical Preparation
    • Expert Patient Care Training

Charlotte, NC

University of North Carolina at Charlotte

  • Master's - Community/Public Health Nursing, M.S.N.

    Online Learning - Website

    • 100% Online Delivery
    • 38 Total Credit Hours
    • 360 Clinical Hours Required
    • Multiple Admission Semesters
    • Requires Unrestricted RN License
    • Minimum 3.0 GPA Preferred
    • Comprehensive Career Opportunities
    • Quad Council Competency Alignment
  • Master's - Adult-Gerontology Acute Care Nurse Practitioner

    Campus Based - Website

    • 47 graduate credit hours
    • 600 hours clinical experience
    • Partnered with Carolinas Healthcare System
    • Certification exam preparation
    • Minimum 3.0 GPA requirement
    • Full and part-time options
    • Evening class schedules
  • Master's - Nurse Educator, M.S.N.

    Online Learning - Website

    • 100% online program
    • 39 total credit hours
    • Admits spring/summer/fall
    • Resident tuition $288.82/credit
    • Requires 1 year nursing practice
    • NLN certification eligible
    • Clinical practicum included
    • 3.0 GPA preferred
  • Master's - Adult Psychiatric Mental Health

    Campus Based - Website

    • Advanced nursing specialization
    • Comprehensive mental health focus
    • Clinical skill development
    • Evidence-based practice training
    • Part of CCNE-seeking accredited nursing program
  • Master's - Nurse Administration, MSN

    Online Learning - Website

    • 100% Online Delivery
    • 27 Months Part-Time
    • 36 Total Credit Hours
    • ANCC Certification Prep
    • $111,900 Average Wage
    • Flexible Admission Semesters
    • 360 Clinical Hours Required
    • 3.0 Minimum GPA
  • Master's - Family Nurse Practitioner Across the Lifespan

    Concentration: Across the Lifespan - Campus Based - Website

    • Primary care across lifespan focus
    • Board certification preparation
    • Multiple practice settings available
    • Wellness and prevention emphasis
    • Comprehensive healthcare leadership

Durham, NC

Duke University

  • Master's - Adult-Gerontology Primary Care Nurse Practitioner MSN

    Online & Campus Based - Website

    • #1 Ranked NP Program Nationwide
    • 42-credit hour flexible curriculum
    • 560+ clinical training hours
    • Online and hybrid learning options
    • Expansive clinical partnership network
    • Focus on health equity
    • Comprehensive patient care approach
  • Master's - Adult-Gerontology Acute Care Nurse Practitioner

    Online & Campus Based - Website

    • Nationally ranked #1 AGACNP program
    • Hybrid distance-based learning
    • Global clinical placement network
    • Focus on health equity
    • Extensive clinical simulation experiences
  • Master's - Psychiatric-Mental Health Nurse Practitioner MSN

    Online & Campus Based - Website

    • #1 Mental Health Nursing Program
    • Hybrid Learning Model
    • Nationwide Clinical Partnerships
    • Distance-Based Education Options
    • Comprehensive Mental Health Training
    • Expert Faculty with Clinical Experience
    • Diverse Career Opportunities
    • 38% Job Growth Projection
  • Master's - MSN in Health Informatics

    Online & Campus Based - Website

    • Hybrid online/campus learning
    • 224 clinical practicum hours
    • Top 3 Nursing Schools ranking
    • Distance-based interactive courses
    • Meets national informatics standards
    • Personalized learning approach
    • Advanced technology training
    • Competitive career opportunities
  • Master's - Women's Health Nurse Practitioner

    Online & Campus Based - Website

    • Hybrid learning format
    • Ranked #3 Nursing School
    • Distance-based curriculum
    • Clinical placement support
    • Personalized mentorship
    • Lowest credit requirements
    • Advanced clinical training
    • Nationwide career opportunities
  • Master's - Pediatric Acute Care Nurse Practitioner MSN

    Online & Campus Based - Website

    • Pediatric Acute Care MSN
    • Hybrid program
    • Distance-based learning
    • Worldwide clinical network
    • Clinical practice experience
    • Diverse clinical settings
    • Focus on family-centered care
    • Culturally sensitive care
  • Master's - Pediatric Primary Care Nurse Practitioner MSN

    Online & Campus Based - Website

    • Distance-based hybrid learning
    • Dual certification opportunity
    • Global clinical placement network
    • Extensive clinical simulation
    • Comprehensive pediatric curriculum
    • Holistic admissions approach
    • Faculty with real-world experience

Greensboro, NC

University of North Carolina at Greensboro

  • Master's - Master of Science in Nursing

    Concentration: Family Nurse Practitioner - Online & Campus Based - Website

    • 5 semester full-time program
    • Hybrid learning format
    • 44 total credit hours
    • 540 total clinical hours
    • National certification preparation
    • Full and part-time options
    • UNCG secures preceptors
    • Application deadline May 1st

Greenville, NC

East Carolina University

  • Master's - Nurse-Midwifery

    Online & Campus Based - Website

    • Masters or Post Masters Certificate
    • Hybrid program format
    • AMCB certification preparation
    • Advanced nursing practice focus
    • Women's healthcare specialization
  • Master's - Psychiatric-Mental Health Nurse Practitioner

    Online & Campus Based - Website

    • Hybrid online/on-campus format
    • 550 total clinical hours
    • CCNE accredited program
    • Across lifespan clinical practicums
    • Post-Masters Certificate available
    • Limited, competitive admission
    • Two-day campus intensives
    • Professional references required
  • Master's - Master of Science in Nursing / Master of Business Administration

    Concentration: Health Systems Leadership - Online Learning - Website

    • 100% Online Dual Degree Program
    • 64 Semester Hour Concentration
    • No GRE/MAT Required
    • Minimum 2.7 Undergraduate GPA
    • 5+ Years RN Experience Preferred
    • Nursing and Business Integration
    • Health Systems Leadership Focus
    • Professional References Required

Hickory, NC

Lenoir-Rhyne University

  • Master's - Master of Science in Nursing

    Concentration: Nursing Administration - Online Learning - Website

    • Online program format
    • 33 total credit hours
    • Flexible part-time options
    • Leadership-focused curriculum
    • Informatics and ethics courses
    • CCNE accredited program
    • Advanced nursing leadership focus
    • Practicum and capstone experience
  • Master's - Master of Science in Nursing

    Concentration: Nursing Education - Online Learning - Website

    • Online program availability
    • 39 total credit hours
    • Part-time and full-time options
    • CCNE Accredited program
    • Advanced nursing core courses
    • Direct care core included
    • Practicum and capstone experience
    • Focuses on teaching and learning

Pembroke, NC

University of North Carolina at Pembroke

  • Master's - Master of Science in Nursing

    Concentration: Clinical Nurse Leader - Online & Campus Based - Website

    • Hybrid program format.
    • Prepares for CNL certification.
    • 39 semester hours total.
    • Focus on quality and safety.
    • Advanced nursing concepts.
    • Leadership in clinical microsystems.
    • Evidence-based practice focus.
    • Policy and financing of healthcare.

Wilmington, NC

University of North Carolina Wilmington

  • Master's - Master of Science in Nursing – Nurse Educator

    Online Learning - Website

    • Fully online program
    • 36 credit hours total
    • Can complete in 12 months
    • Prepare for nurse educator roles
    • Multiple start dates in 2025
    • Minimum 3.0 GPA required
    • Statistics course prerequisite
    • Active nursing license needed

Wilson, NC

Barton College

  • Master's - Master of Science in Nursing

    Concentration: Education - Campus Based - Website

    • MSN Education Concentration available
    • 39 total credit hours
    • Two-year part-time program
    • Advanced clinical and teaching courses
    • Includes advanced practicum
    • Covers health assessment skills
    • Includes advanced pathophysiology
    • Advanced pharmacology training

Winston-Salem, NC

Barton College

  • Master's - Master of Science in Nursing

    Concentration: Education - Campus Based - Website

    • MSN Education Concentration available
    • 39 total credit hours
    • Two-year part-time program
    • Advanced clinical and teaching courses
    • Includes advanced practicum
    • Covers health assessment skills
    • Includes advanced pathophysiology
    • Advanced pharmacology training